Welcome to Orgasm Research Center
Suffering is Believing (This is what you don't want to know!)
or get Benefits from Optimal Orgasms (This is what you love to hear about) or More!

Sexual arousal or orgasm triggers the neuro-immuno-endocrine function for better or worse, depending on the immunoreaction of the noradrenergic (norepinephrine)/sympathetic nervous system to its resulted stress  and on the balance of its induced pro-inflammatory and anti-inflammatory responses. If you ignore the neuro-immune responses to sex-induced stressors norepinephrine and epinephrine, sex will destroy your health for no more orgasm, but pains and psychological disorders like drug abuse.  The neuro-immune-endocrine responses to sex-induced stress are driven by the sympathetic nervous alpha- and beta-andrenergic receptors of the immune cells which release immunotransitters cytockines and protein kinases for pro-inflammation or/and anti-inflammation. The classic Taoism teaching considers sex as a powerful drug for better or worse, up to individual practices. OK,  we provide the  following topics for you, so that you can understand why sex is not for entertainment:
1. Destruction of Excessive Orgasms(for men and women) - About 5-10% of over-masturbators get permanently damaged! God punishes the self-destructors! Don't become one of them! Or you have to pay a high price for the consequence.
2. Male Ejaculatory Frequency and Seasonal Change vs Semen Quality
3. Male Ejaculation Frequency vs. Testosterone Level - Psychological (Sexual) Stress locks up the hypothalamus-pituitary-adrenal and testicular axis via cortisol, prolactin and inflammatory hormone prostaglandin E2
4. Sex as an Addictive Drug (but, can we retrain old dogs with new tricks to reverse addiction?)- the neuroplasticity of the hypothalamus by norepinephrine and its induced prostaglandin E2(for men and women) 
5. Excessive sex for darker eye cycles, nips, labia minors, pelvic area, perineum, clitoral and penile foreskin
6. Benefits from Optimal Orgasms(for men and women)
7. Brain-Skin/Brain-Hair connection - the effect of excessive sex-induced stress on skin (acne) and hair (hair loss) (for men and women)
8.  Sex-stress (Norepinephrine/ Epinephrine)  induced Inflammatory Pains, Headaches and Hangover  (for men and women)-  Norepinephrine-induced prostaglandin E2 release sets the brain and body on fire for sexual arousal/orgasm and pains
9. Persistently Sexual Arousal (breeding) or Over-ejaculation (Frequent Orgasm) Reducing/Suppressing Male Immune Function via Norepinephrine Induced Prostaglandin E2 Release
10. Liver/organs malfunction and inflammation and Hypothalamus-Pituitary-Adrenal  impairement - ageing - induced by sex stress with chronic elevation of immunotransmitter cytokines and inflammatory hormone prostaglandin E2 (for men and women)
11. Orgasm Brain Sex Pain examples (for men and women)

Destruction of Excessive Orgasms
After you enjoyed too many sexual orgasms and/or too much pleasure, you have likely blown your brain/nervous bioelectric circuit breaker, and may have started to deal with the Sexual Exhaustion Symptoms - the exhaustion of the hypothalamus-pituitary-adrenal/-testicular (-ovarian) axis (cases are listed in Over.htm, Over2.htm, Over3.htm, and GirlOverSex.htm) very possibly or likely including the hypothalamus-pituitary-thyroid dysfunction, and deducing/downgrading or desensitization of the androgen hormonal receptors in the hypothalamus, hippocampus and pituitary, resulting from the Nervous Excitotoxicity and Inflammation induced by excessive norepinephrine, epinephrine and glutamate (& other excitory neurohormones, for a short-term pleasure reward and the long-term dopamine depletion),  long-term excessive elevation of prolactin ( to inhibit GnRH release from the hypothalamus and therefore LH and FSH secretion from the pituitary and to directly desensitize pituitary gonadotropic cells and the Leydig cells of the testes) , and Prostaglandin E2 (the brain heater for the core temperature rise!)  At the sexual exhaustion state, the constant elevation of excessive prolactin (mimics Hyperprolactinaemia) suppress sensitivity of  prolactin-negative feedback on hypothalamic tuberoinfundibular dopaminergic (TIDA) neurons for persistently low dopamine synthesis,  blocks the beta-adrenergic receptors and nitric oxide nervous mechanisms and promotes norepinphrine and epinpehrine binding to the alpha-adrenergic receptors for vasoconstriction and restriction of blood flow to the brain and genitals, and destroys or desensitizes the hypothalamic androgen receptors, as described in
http://jp.physoc.org/cgi/content/abstract/576/2/585 
http://cancerres.aacrjournals.org/cgi/content/abstract/65/17/7984 
http://endo.endojournals.org/cgi/content/abstract/145/12/5714  
http://endo.endojournals.org/cgi/content/abstract/148/8/4080 
http://www3.interscience.wiley.com/journal/118874269/abstract?CRETRY=1&SRETRY=0 
http://www.psy.fsu.edu/faculty/hull/D&H_review.pdf  
http://ep.physoc.org/cgi/content/abstract/91/3/603 
http://jp.physoc.org/cgi/content/abstract/557/1/307  
http://endo.endojournals.org/cgi/content/full/147/3/1195
Cutting down the brain and genital blood circulation naturally alternates the neurotransmitters and hormonal syntheses, the major brain nervous function including the dopamine, acetylcholine, serotonin, GABA, noradrenergic, adrenergic, glutamate, oxytocin, nitric-oxide(NO), vagal and autonomic nerves functions,  and the hypothalamus-pituitary-adrenal and -testicular(-ovarian) function.
The Traditional Chinese Medicine has termed the hypothalamus-pituitary-adrenal (HPA) exhaustion as "Kidney Deficiency", since the classic Chinese anatomy text assumed the tiny adrenal gland, sitting on the top of  the kidney, is a part of the kidney about 2000 years ago. The HPA exhaustion results in the erratic release of CRH (corticotropin releasing hormone), POMC (proopinomelanocortin),  ACTH (adrenocorticotropc hormone),  ß-lipotropic hormone, ß-endorphin, α-melanocyte-stimulating hormone (α-MSH),  ß-MSH, CA (catecholamines) and TSH (thyroid stimulation hormone), in response to stress, sex and environmental/dyshomeostatic stimuli.  Since skin and hair follicles also display a functional equivalent of the HPA axis, sexual exhaustion will also extensively affect your skin (for examples: darkening skins in certain areas such as eye cycles, nips, labia minors, foreskin, perineum and groins, due to excessive release or trapping of the POMC peptide α-MSH which is also an anti-inflammatory and immunomodulating hormone - anti-tissue abrasion!) and the hair (for examples: hair loss in the scalp and gray hair, but it won't grow hair in your palms although it will destroy your HPA axis.)  The explanation of the HPA, skin and hair connection are given in the following links: http://edrv.endojournals.org/cgi/reprint/21/5/457, http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1839836&blobtype=pdf , http://www.fasebj.org/cgi/reprint/04-1968fjev1.pdf,  http://www.tufts.edu/sackler/pharmacology/faculty/theoharides/documents/TiI-brain-skin.pdf , http://physrev.physiology.org/cgi/reprint/80/3/979 , http://ard.bmj.com/cgi/content/abstract/66/suppl_3/iii52 , http://www.ncbi.nlm.nih.gov/pubmed/12576179 , http://www.fasebj.org/cgi/reprint/19/10/1332.pdf, http://www.annalsnyas.org/cgi/content/abstract/885/1/350 , and http://www.jci.org/articles/view/33508/pdf
As a result, sex is like a good investment with a bad return. When you reach the neuro-endocrine breaking point, it is like the stoke market cash leading to the great depression!! Yes,  excessive sex induces psychological and physiological disorders.

For example:
Destructive over-masturbation practices at 3-5 times a day resulted in brain fires and hydraulic shock waves, unconsciousness, panics, rapid heart beat, hypertension, short breathing, chest weird feeling urination difficulty, and frequent urination.
==> http://www.actionlove.com/cases/case15882.htm
After sexually exhausting his the brain's and internal Hypothalamus-Pituitary-Adrenal (HPA) axis, he has gotten headache and felt death and exhaustion from wet dream, even once a weak. Why he felt worse on the 2nd day after ejaculation? He may have to rely on  the Cutaneous Hypothalamus-Pituitary-Adrenal (CHPA) function to assist post-ejaculation or post-orgasm recovery.
http://www.actionlove.com/cases/case15761.htm
Excessive dopamine-norepinephrine/epinephrine induced excessive prostaglandin E2 production to elevate core temperature for over-heating brain, skin and hair follicles' neuro-endocrine function,  leading  to dark eyes, enlarged eye pupils, low testosterone, hot flushes, low libido,  cognitive disorders, and  speed disorders.
==> http://www.actionlove.com/cases/case15821.htm
Why psychological stress (excessive norepinephrine/epinephrine) induced excessive prostaglandin E2 production to elevate core temperature for over-heating brain, skin and hair follicles' neuro-endocrine function,leading to no erection, dark eyes, enlarged eye pupils, low testosterone, low libido, erectile dysfunction,  cognitive disorders and testicular disorders for no sexual orgasm - solution
==> http://www.actionlove.com/cases/case15822.htm
Chronic over-stress in war zone results in Posttraumatic Stress Disorder (PTSD), traumatic brain injury (TBI), depression, panic and erectile disorders due to serotonin/GABA neuroplasticity in hypothalamus, hippocampus and adrenal glands - Dr. Lin's proposed solution for neuroplasticity reversal.
http://www.actionlove.com/cases/case15877.htm

After our 10-year case collection and research, we now understand why excessive sex and drug abuses are so destructive. We are able to zoom into the main causes:
(1).  Sex-induced excessive excitory neurohormones norepinephrine/epinephrine/glutamate/histamine production for nervous toxicity: According to a American Scientists's report - http://www.americanscientist.org/template/AssetDetailNoFrame;jsessionid=aaaaBjcbX4%0D%0AuGmh?assetId=49707),   epinephrine can easily penetrate the mouse's blood-brain barrier into the limbic system, and allow lupus-like autoantibodies to reach the amygdala, where " the antibodies bind to and overactivate certain cell receptors, eventually killing the cells through excitotoxicity."  Excessive dopamine-norepinephrine-epinephrine conversion during sexual arousal/orgasm/ejaculation will drop the dopamine level (yes, for dopamine excitotoxicity prevention and rewarding pleasure if your dopamine level is too high!) , leading to excessive pituitary prolactin release to cause testicular and ovarian disorders, and keep the stress neurohormone norepinephrine or/and epinephrine in the excitotoxicity level. Our readers also reported chronic excessive orgasm/ejaculation induced seizure, headache, migraine, blackout, allergy, asthma, eye floaters and ear ringing (tinnitus), as a result of nervous excitotoxicity induced by excessive norepinephrine, epinephrine (particularly this one), glutamate or/and histamine. Prolonged and repeated assaults on the hippocampus nerve cell structure may permanently fry your brain. (Here are the other recent research examples:
http://jcem.endojournals.org/cgi/reprint/87/9/4245
http://www.biomedcentral.com/1471-2172/5/22
http://circ.ahajournals.org/cgi/content/full/102/1/96
http://www.algonot.com/pdf/mastcellsinflammation.pdf
http://www.ionchannels.org/showabstract.php?pmid=15970488
http://www.pnas.org/cgi/reprint/103/3/678
http://www.sciencemag.org/cgi/content/abstract/174/4008/512,
http://www.pnas.org/cgi/content/full/96/12/7093
http://ajpheart.physiology.org/cgi/content/full/289/4/H1577 
http://jcem.endojournals.org/cgi/content/full/89/5/2000
http://www.anesthesia-analgesia.org/cgi/content/full/100/2/520
http://www.osti.gov/energycitations/product.biblio.jsp?osti_id=6793231, as addressed in this link-
How to kick the pornography addiction:  Reduction of the inflammatory hormone prostaglandin E2 production, Excessive epinephrine and norepinephrine induces inflammatory responses, persistent sexual arousal, and brain/nervous excitotocixity, and enhancement of the serotonin and GABA nervous modulation and control
==> http://www.actionlove.com/cases/case15570.htm). 
Dopamine and glutamate are essential for sex. For healthy person, sexual stimulation elevates the dopamine and glutamate synthesis. Excessive dopamine triggers the stress hormone production and promotes the liver P450 enzymes and Monoamine oxidases (MAO) to  deamination of dopamine and stress hormones. In addition to elevating the stress hormones norepinephrine and epinephrine,  chronic excessive sexual stimulation, excessive orgasm, over-masturbation/over ejaculation, or drug abuse will result in excessive glutamate release or accumulation due to a shortage of the enzyme L-glutamic acid decarboxylase and pyridoxal phosphate in efficiently converting elevating glutamate into GABA during sex, or/and due to a shortage of the enzymes gamma-glutamylcysteine synthetase and glutathione synthetase or/and a shortage of  amino acids L-cysteine and glycine, in converting elevating glutamate into the liver detoxification promoter Glutathione.   Elevation of GABA with serotonin, norepinephrine and prolactin after sex or orgasm will trigger the pineal gland to release melatonin for sleeping and restoration;  Elevating of glutathione can reduce the formation of  oxidative toxins, such as Hydrogen peroxide (H₂O₂),  associated with oxidative injury and cellular/nervous damage. Of course, you will benefit from sex and orgasm if you get a resulted elevation of both GABA and glutathione.  However,  when the liver are stressed out by orgasm, over-ejaculation, drugs, and aged/toxified by the monoamine oxidization toxins, the liver can not efficiently provide the enzyme L-glutamic acid decarboxylase and pyridoxal phosphate for glutamate-GABA conversion, leading to accumulation of glutamate in the brain/nervous systems and cerebrospinal fluid for ultimate nervous and brain destruction. ( Note that increasing the conversion of L-arginine to the inhibitory neurotransmitter agmatine can help block the action of glutamate on the NMDA receptor and acts as a neuromodulator. This is an important mechanism in preventing the harmful effects of excess glutamate. Agmatine is decarboxylated argenine. Studies shows agmatine can reverse pain induced by inflammation, neuropathy, and spinal cord injury - http://www.pnas.org/cgi/content/abstract/97/19/10584 ).

Furthermore, chronically excessive sexual arousal, over-ejaculation (overmaturbation), excessive orgasms or/and drug abuse can hyperativate the enzyme Monoamine oxidases (MAO) for dopamine-DOPAL conversion , where DOPAL stands for 3,4-dihydroxyphenylacetaldehyde.  DOPAL is a potent neurotoxin to cause Parkinson's-like brain lesions, and its resulted cognitive impairment is very similar to autism. In addition to DOPAL, norepinephine and epinephrine can be converted to 3,4-dihydroxyphenylglycoaldehyde (DOPEGAL) by MAO too. DOPEGAL has been found to trigger apoptosis and cause the loss of CNS neurons. Therefore, the synergic destructive effects of both DOPAL and DOPEGAL accelerates death of nerve cells, as seen in SIDS (sudden infant death syndrome), Alzheimer’s, Parkinson’s disease, and dysfunctional disorders of development and aging.

Overmasturbation resulted in Parkinson's symptom - restless or shivering legs and hands - due to abrupt drop of dopamine for excessive dopamine-neorepinephrine-epinephrine-DOPEGAL (3,4-dihydroxyphenylacetaldehyde) and dopamine-DOPAL(3,4-dihydroxyphenylacetic acid) conversion, leading to neurotoxicity and nervous death for no more sexual orgasm
==> http://www.actionlove.com/cases/case15611.htm

MAO, the brain/nervous and liver enzyme,  exists virtually in all mammalian cell types, with the notable exception of the erythrocyte. Excessive monoamines such as dopamine, norepinephrine and epinephrine induced by chronic stress, excessive sexual stimulation and orgasm and/or drugs will activate the liver Cytochrome P450 and MAO for oxidization (deamination) and detoxification, as described above, in order to maintain the homeostasis of the brain and nervous function. But, unfortunately, the resulting toxins destroy or damage the local neurons or synapses. In humans, there are two types of MAO: MAO-A and MAO-B. Both are found in neurons, hypothalamus, cerebral cortex (conscious control center), cerebellar cortex, pons, medulla oblongata, substantia nigra, caudate, astroglia, skins, and skeletal muscles.  Outside the brain and central nervous system, the liver, gastrointestinal tract , adrenal glands, kidnes, heart, lungs, and placenta have about 60-90% MAO-A and 10-40% MAO-B, but, MAO-B is mostly found in blood platelets. MAO's are enzymes that catalyze the oxidation of monoamines. They are found bound to the outer membrane of mitochondria in most cell types in the body. After placenta, liver contains the highest level of MAO, followed by kidneys, adrenal glands, heart, hypothalamus, substania nigra, lungs, intestine, caudate, medulla oblongata, pons, cerebral cortex and cerebellar cortex. That is, the liver, kidneys, adrenal glands, heart,  hypothalamus and substania nigra are likely aged or damaged by the  MAO-deaminated or oxidized toxins DOPAL, DOPEGAL, hydrogen peroxide (H₂O₂) and 5-Hydroxyindoleacetic acid (5-HIAA, as discussed below) faster than the other organs, and the liver will be damaged first. 
The main substrates of MAO-A include dopamine, serotonin, norepinephrine, epinephrine, octopamine, tyramine and tryptamine; the main subtstrates of MAO-B include dopamine, phenylethylamine, -phenylethylamine (PEA),  benzylamine, MPTP (1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine),  tyramine, and tryptamine. 
MAO plays the key roles in the development of neurodegenerative disease,  including not only its putative role in converting an exogenous protoxin to a toxin, as mentioned above, but also its role in the formation of peroxides generated from the oxidative metabolism of dopamine.  MAO catalyzed deamination of dopamine to DOPAL and production of hydrogen peroxide (H₂O₂) and ammonia NH₃ depend on concentrations of dopamine within the cytoplasm. Hydrogen peroxide, if not detoxified by glutathione peroxidase, can be converted by iron-mediated Fenton reactions to toxic hydroxyl radicals ( -OH) that induce lipid peroxidation and cell death. In addition, excessive ammonia accumulation in the bloodstream, termed as hyperammonemia,  can cause the confusion and coma of hepatic encephalopathy as well as the neurologic disease.     On the other hand, MAO-A breaks down serotonin into 5-Hydroxyindoleacetic acid (5-HIAA) and steals serotonin from arylalklamine N-acetyltransferase (AANAT), resulting in depleting the melatonin synthesis. Melatonin plays the key role for the mechanisms of circadian rhythm for healing the damaged cells while 5-HIAA is responsible for the developments of certain tumors or cancers.  Graveyard workers are at risk due to hyperactivities of MAO.  Our product DeToxiA, MoodMax, ViaGrowth-IV, PinealTonin and ArgiNOx have been formulated  to help you reduce the MAO gene expression (or weaken the MAO activities in the dopamine, serotonin, norepinephrine and epinephrine nervous terminals) and hydrogen peroxide (H₂O₂)  formation, and enhance the liver urea cycle to remove ammonia NH₃ from the blood stream (that is, detoxification of the nervous system, liver and blood!)
Most recent studies also indicate there is significant positive correlations between platelet MAO activity and cortisol measures. In normal sexual activities, orgasm or ejaculation is supposed to drop the cortisol level and to elevate norepinephrine and epinephrine level. If MAO turns serotonin into 5-HIAA and depletes serotonin production during or after sex, the post-sex elevation of norepinephrine and epinephrine will activate the MAO action on the adrenal cortex for excessive cortisol elevation several hours after the cortisol drop induced by ejaculation or orgasm.  Cortisol overshooting suppresses the adrenal DHEA production and testicular function, resulting depletion of androgen hormones in the brain,  and then causes post-sex hangover,  memory loss and depression in the next few days.  Maintaining a high level of cortisol will suppress immune function, promote atherosclerosis, and damage and kill brain cells eventually.  Excessive sex, orgasm or ejaculation, or/and drug abuse for pleasure rewarding or/and sexual enhancements can let you experience both hypocortisolism and hypercortisolism in your daily life when the cortisol diurnal rhythm is disturbed or the cortisol level is too low in the certain time of a day, but becomes over-shooting in the other time.  The complicated symptoms induced by sexual practices was named as Sexual Exhaustion Symptoms by Dr. Lin, as given in http://www.actionlove.com/cases/case9848.htm.

• Hypocortisolism:  an abrupt drop of cortisol with symptoms of Addison's disease symptoms and others,
  including: fatigue, muscle weakness, weight loss, vomiting, diarrhea or digestive panic responses, headache, sweating, bipolar, mood swing, OCD, and joint and muscle pains;  goiter; vitiligo; dark eye circles; darkening (hyperpigmentation) of the skin, including areas not exposed to the sun, such as groins nipples, penis, testicles, labia majors and minors, and the inside of the cheek (buccal mucosa); orthostatic hypotension; cravings for salt or salty foods due to the urinary losses of sodium. 
• Hypercortisolism: an excessive level of cortisol in the bloodstream resulting in the so-called Cushing's syndrome and others, 
  including: rapid weight gain or central obesity; moon face; excess sympathetic nervous sweating, telangiectasia (dilation of capillaries); thinning of the skin for easy bruising or inflaming, particularly in the penis, testicles, face, breasts, hands, legs and other mucous membranes;  purple or red striae ;hirsutism;  insomnia; reduced libido; impotence; amenorrhoea;infertility; euphoria; psychosis; depression; anxiety; persistent hypertension (due to cortisol's enhancement of epinephrine's vasoconstrictive effect and binding into the adrenergic alpha-2 receptors); insulin resistance (especially common in ectopic ACTH production), leading to hyperglycemia (high blood sugars) which can lead to diabetes mellitus; heart disease; hyperpigmentation, resulting from Melanocyte-Stimulating Hormone production as a byproduct of ACTH synthesis from Proopiomelanocortin (POMC); abnormal mineralcorticoid to worsen the hypertension and to hypokalemia;  gastrointestinal disturbances;  immune disorders; impairment of wound healing; osteoporosis since the cortisol suppresses adrenal, testicular and ovarian function.  
  

(2). Sex-induced excessive inflammatory hormone prostaglandin E2 production, due to the excessive excitory neurohormones and the deficiency of androgen hormones (due to the disabling of the testicular and ovarian function by an excessive, persistent prolactin elevation at about 2-4 hours after orgasm/ejaculation):  In this regard, prostaglandin E2 induced body pain or inflammation originally serves as a warning sign of excessive sex.  If you ignore the warning signal, prostaglandin E2 will eventually give you more, including  inflammation responses, cellular multiplication, nervous excitation (for androgen hormone production and memory neuroplasticity (the good), inflammatory orgasm (the bad) and persistent sexual arousal and synaptic damage (the ugly)), nervous exitotoxcity and immune suppression.  Prostaglandin E2  induces enhancement of synaptic transmission is mediated via a cAMP/PKA(Protein Kinase A) pathway.  Prostaglandin E2 plays an important role in fever, pain, inflammation, sleep disorders, regulation of membrane excitability, sexual behavior, synaptic transmission, integration, neurotoxicity neuroplasticity, and neurologic disorders such as epilepsy and Alzheimer's disease. Excessive prostaglandin E2 can also degrade the short time memory and spatial navigation by enhancing membrane excitability (burning the synapse out) and then causing long-term damaged synaptic neuroplasticity in hippocampal perforant path-dentate gyrus synapses. Sexual pleasure and images will be imprinted  in your hippocampus by synaptic neuroplasticity resulted from the orgasm-induced prostaglandin E2 with a help of calcium channel of the synapse,  like remembering what you learn, hear, or see in daily life. Neuroplasticity is essential to learning and memory, like burning data into EEPROM. In eleccronic circuit, EEPROM can be eased and re-written.  I think our hippocampus can be reprogrammed by neuroplasticity (reversing sex and drug addition), with long-term potentiation (LTP) and long-term memory (LTM) formation, like training old dogs new tricks. However, if you apply a voltage to a memory cell higher than the upper limit of the EEPROM biased voltage, you will burn the memory cell out.  This condition also happens to your hippocampus.  Prostaglandin E-2 amplifies the excitatory post synaptic potentials (EPSPs) and heats the neuron and its synapse. Repeating the stimulation of the neuron and its synapse over time with accumulation of prostaglandin E2 will increase the action potential (accumulatively) in the neuron and synapse to cause the permanent deformation (forever memory) or damage (electrical overloading or thermal overheating ) of the synapse and neuron.  It can happen in the short time when prostaglandin E2 is excessive under a high-stress. extreme or/and shock condition. For this reason, you always remember your first-time masturbation and sexual intercourse.  In addition, persistent action of prostaglandin E2 on a cell will eventually alternate the cellular gene for potential cancerous or tumor development.  For examples, excessive prostaglandin E2 causes inflammation, enlargement, tumor and even cancers in the prostate, breasts, uterus and cervix.  Ref: http://jnnp.bmj.com/cgi/content/abstract/77/1/85 
http://bmc.ub.uni-potsdam.de/1471-2202-6-14/ 
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=356994 
http://ajpgi.physiology.org/cgi/content/full/274/3/G493  http://jn.physiology.org/cgi/reprint/93/2/929?ijkey=a9024b9ce74ad6d9ccd2311f9f39ee084760b417, http://jpet.aspetjournals.org/cgi/reprint/293/2/417?ijkey=3badb86cdf65c4b7c1d53623aea092cf7279b9b2 , http://jn.physiology.org/cgi/content/abstract/87/6/2851?ijkey=5cee184dd3946b4945f9cc00585dec35e2d51349&keytype2=tf_ipsecsha
http://cancerres.aacrjournals.org/cgi/content/abstract/65/12/5211 
http://www.jbc.org/cgi/content/abstract/263/11/5380 
http://www.annalssurgicaloncology.org/cgi/content/full/10/4/469 
http://cancerres.aacrjournals.org/cgi/content/abstract/63/17/5218 
http://cancerres.aacrjournals.org/cgi/content/abstract/65/2/657 
http://www.spacedu.com/ereprints/prostatecfos.pdf 
http://www.ncbi.nlm.nih.gov/pubmed/16293724 
http://www.pnas.org/cgi/content/short/101/2/415 
http://www.jneurosci.org/cgi/content/full/25/43/9858#REF41
http://pharmrev.aspetjournals.org/cgi/reprint/58/1/115.pdf
http://www.nature.com/mp/journal/v5/n6/full/4000811a.html  
http://www.cellscience.com/Reviews5/Ca2+_stimulated_Adenylyl_Cyclases_Hippocampal_Neuroplasticity.html

In addition, excessive sex or/and drug abuse also alternate the functions of the hypothalamus-pituitary-adrenal axis (HPA) and the sympathetic adrenomedullary system.  In addition to body pains and inflammation, our readers have also reported sex-or drug-induced memory loss, absent mindedness,  no concentration, less focusing,  hangover, or pseudo-Alzheimer's symptoms.  These problems can be associated with an overshooting of cortisol. In the normal condition, the sexual activities should not increase the cortisol level unless sexual arousal or orgasm induces inflammation; instead, normal sex tends to slightly reduce the cortisol level for activation of the pituitary-adrenal and -testicular function during and after sex.   In some case, the cortisol level drops too low, low enough to activate the inflammatory factors, leading to sex-induced pains , cramps or headaches while the norepinephrine and epinephrine level shoot up or remain too high. During sexual arousal, if the cortisol level shoots up (Note:  prolonged exercises overshoot cortisol, epinephrine, norepinephrine, Glucagon and growth hormones at the same time for a hyper-sympathetic nervous Fight), the prolactin level will follow; the man will go limp and the women will becomes dry; the lovemaking couples will experience sympathetic nervous Flight responses and the sexual arousal will be terminated. The release of cortisol, from the adrenal cortex,  is supposed to suppress the activities of the pro-inflammatory factors induced by an elevation of epinephrine, norepinephrine or/and histamine when the hypothalamus-pituitary-adrenal axis (HPA) responds to sexual arousal,  orgasm, masturbation, ejaculation, stress or drugs.   Under chronic loading of sexual arousal,  orgasm, masturbation, ejaculation, stress or drugs, the HPA can respond in 2 ways:  either abruptly dropping cortisol or excessively releasing cortisol.  If the adrenal cortex  released insufficient cortisol, the patients will experience immediate shape pain or mood change when the epinephrine, norepinephrine or/and histamine level overshoot out of the normal range.  

Under adrenal fatigue or deficiency conditions, the patient can experience the deficiency of both cortisol and androgen hormones (DHEA, testosterone or DHT), leading to persistent and severe body pains or inflammatory responses.

On the other hand,  if the adrenal cortex persistently shoot up the cortisol level and keep it high, the patient will experience foggy brain, memory/contraction/focusing loss, sleeping disorder,  and hangover in next few days. If either prolactin or cortisol level maintains too high, high enough to slow or shut down the adrenal and testicular function, leading to deficiency of DHEA, androstenedione, testosterone or/and DHT,  the patient will also experience post-sex inflammatory body pains, cramps or muscular rigidity due to excessive prostaglandin E2 production as a warning sign. The inflammatory responses usually occurs in few hours and the next day when the DHEA, androstenedione, testosterone or/and DHT are used up and drop down to deficient levels, too low to suppress the pro-inflammatory responses induced by excessive epinephrine and/or, norepinephrine.  
A chronic elevation of cortisol in the cerebrospinal fluid will cause depression and memory loss since cortisol can shrink or atrophy the hippocampus, associated with many kinds of memory and learning.  Unfortunately, under the conditions of chronically excessive sex/orgasm or over-masturbation/over-ejaculation, prolonged stress or drug abuse, excessive release of epinephrine, norepinephrine or/and histamine will open the brain-blood barrier (BBB) for more cortisol and other toxins to cross the BBB to pollute the cerebrospinal fluid and then to shrink the hippocampus,  like the elderly people experience.

Memory, brain and nervous functions can be also associated with Phosphorylcholine, a molecule mainly secreted by the seminal vesicle.  But, Dawson also reported that phosphorylcholine can also be found in the rat liver, testicles, spleen, intestines, kidney and brain, but there is only trace amounts in muscles, heart and blood, as given in http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1215699 and http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1215984.  More recently, it was found that the phosphorylcholine synthesis also occurs in the photoreceptors in supporting the eye visual sensing system (for example, http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=348559&blobtype=pdf ).  Phosphorylcholine combines with ceramide through a phosphodiester bond to create sphingomyelin, an important compound in the formation of the myelin sheath. Stroke victims and Alzheimer patients have shown improvement by increasing the phosphorylcholine level. In rat studies, tissue examination showed that phosphorylcholine was able to help repair damaged neurons. Phosphorylcholine was also found to help prevent a drug-induced drop in acetylcholine levels and improve memory and cognitive function ( http://www.fasebj.org/cgi/content/full/14/14/2198 ).  Over-ejaculation or excessive orgasm burns out, interrupts or discharges excessive phosphorylcholine and may let you experience poor memory or concentration and visual disorders.  I suspect that the depletion of phosphorylcholine synthesis induced by excessive ejaculation or orgasm, in conjunction with neuroexcitotocity of glutamate/norepinephrine/epinephrine and monoamine oxidization toxins (3,4-dihydroxyphenylacetaldehyde(DOPAL), 3,4-dihydroxyphenylglycoaldehyde (DOPEGAL), hydrogen peroxide (H₂O₂) and 5-Hydroxyindoleacetic acid (5-HIAA)), its resulted excessive release of  prolactin/cortisol and prostaglandin E2,  and its resulted deficiency of androgen hormones, leads to premature onset of Alzheimer's and Parkinson's disease, brain/nervous damage, liver/spleen/digestive/testicular disorders, cardiovascular disorders, and poor vision.  
Note:
Semen has high concentrations of potassium, zinc, calcium, magnesium, citric acid, fructose, phosphorylcholine, spermine, prostatic acid phosphatase, free amino acids, prostaglandins and enzymes, which nourish and protect the sperm.  Due to the high concentration of Phosphorylcholine in semen, the old Taoists theorized that men can return semen (actually phosphorylcholine) to revert the brain. Generally speaking, the concept is correct; however,  when the brain's dopamine or testosterone level is too high for excessive semen production, you still have to ejaculate to burn the dopamine and testosterone and to induce the prolactin release in the pituitary and retina for some protective and anti-inflammatory hormone 16K-prolactin to cool down the nervous systems, so that you can avoid the side effects of excessive dopamine or testosterone.  In this way, you can benefit from sex. Note that testosterone and acetylcholine can excite the dopamine-hypothalamus-pituitary axis and oxytocin release for sex.
Futhermore, Semen contains a lot of GABA ( http://www.andrologyjournal.org/cgi/content/full/25/1/140 , http://www.ncbi.nlm.nih.gov/pubmed/6237538?ordinalpos=1&itool= EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlusDrugs1 ) and beta-endorphin http://www.ncbi.nlm.nih.gov/pubmed/6291653?ordinalpos=1&itool= EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlusDrugs1 , http://www.ncbi.nlm.nih.gov/pubmed/2216060?ordinalpos=8&itool= EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum), both of which are the calm/inhibitory neurochemicals.  For a healthy man, ejaculation triggers glutamate-GABA conversion with the liver enzyme glutamate decarbozylase while glutamine is converted to glutamate by the liver enzymes glutamate synthase and synthelase.  In a male rates model, the cerebrospinal fluid(CSF)'s GABA and Asparagine/glutamate concentration increases 1000% and 200%, respectively, and there is a small decrements in amino accids such as serine, arginine, Alanine and leucine ( http://www.ncbi.nlm.nih.gov/pubmed/2877423?ordinalpos=4&itool=
EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum. ).  If there is a lack of  the liver enzyme glutamate decarbozylase, glutamate in CSF becomes too high and GABA becomes too low. This is why ejaculation causes deficiency of GABA and excessive glutmamte for the brain and nervous instability and sympathetic nervous Fight or Flight responses. Semen's GABA and beta-endorphin in the vaginal and cervix can block the female dopamine, oxytcoin and glutamate nervous excitation in the brain via the pituitary-uterus/cervix vagal nervous pathway, Both GABA and beta-endorphin also increase the female cerebrospinal fluid's GABA and beta-endocrine concentration right after male ejaculation, leading to calming the female central nervous system and reducing the oxytocin release. That is why premature ejaculation will disable libido immediately, unless the semen's prostaglandin E2 and glutamate can continue exciting the clitoral, G-spot, cervix and uterus vagal nerves. However, semen/CSF's GABA and beta-endorphin can help male and female post-orgasm pains in the urethra, prostate, bladder, clitoris,  vagina, uterus, and tailbone http://endo.endojournals.org/cgi/reprint/145/3/1331. Note: Beta-endorphin is mainly produced by the hypothalamus-pituitary-adrenal and -testicular/Ovarian axis in response to stress.  A sexual exhaustion person will fail to release sufficient beta-endorphin in help suppress pains.  A persistent sexual arousal person lacks of GABA and beta endorphin, but has a high level of glutamate, dopamine, norepinephrine, epinephrine and/or histamine.  Obviously, a person with a lack of serotonin, GABA and beta-endorphin will experience severe anxiety, depression, mood swing, de-realization, irrational thinking, irritation, panic responses, premature ejaculation, penile or clitoral over-sensitivity, and pains.   

Therefore, excessive sex or/and drug abuse result in multiple, sexual exhaustion symptoms which become UFO for western doctors and medical societies, although the Chinese Sex Bible and medicine documented them 5000 years ago.
==> http://www.actionlove.com/cases/case15448.htm
Why great sex life can result in divorce and end his sex life with low libido and headaches.
==> http://www.actionlove.com/cases/case15717.htm
On the effect of ejaculation on the testosterone production and aggressiveness or mode swing. Why it will take about 7 days to release the post-ejaculation or post-orgasm sexual exhaustion symptoms
http://www.actionlove.com/cases/case15719.htm

Ejaculatory Frequency and Seasonal Change vs Semen Quality: according to http://www.ncbi.nlm.nih.gov/pubmed/15302284?dopt=Abstract , Increasing your ejaculatory frequency will drop your sperm concentration, but there is no seasonal variations in sperm concentration, motility, or morphology. Compared with one ejaculation per week, sperm concentration fell 29% with two ejaculations per week, and by 41% with three ejaculations per week.  Noticeable, the spring ejaculatory frequency is significantly higher in spring months than the winter's.  Note:  the pituitary-testicular axis and the skin endocrine function respond to the seasonal temperature change, and more active in warm weather.

Ejaculation Frequency vs. Testosterone Level: 
1. http://www.ncbi.nlm.nih.gov/pubmed/12659241?dopt=Abstract - "The purpose of this study is to gain understanding of the relationship between ejaculation and serum testosterone level in men. The serum testosterone concentrations of 28 volunteers were investigated daily during abstinence periods after ejaculation for two phases. The authors found that the fluctuations of testosterone levels from the 2nd to 5th day of abstinence were minimal. On the 7th day of abstinence, however, a clear peak of serum testosterone appeared, reaching 145.7% of the baseline ( P < 0.01). No regular fluctuation was observed following continuous abstinence after the peak. Ejaculation is the precondition and beginning of the special periodic serum testosterone level variations, which would not occur without ejaculation. The results showed that ejaculation-caused variations were characterized by a peak on the 7th day of abstinence; and that the effective time of an ejaculation is 7 days minimum. These data are the first to document the phenomenon of the periodic change in serum testosterone level; the correlation between ejaculation and periodic change in the serum testosterone level, and the pattern and characteristics of the periodic change."  also in http://www.ncbi.nlm.nih.gov/pubmed/12506329?ordinalpos=2&itool=EntrezSystem2.PEntrez
.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
2. http://www.ncbi.nlm.nih.gov/pubmed/11760788?dopt=Abstract - "This current study examined the effect of a 3-week period of sexual abstinence on the neuroendocrine response to masturbation-induced orgasm. Hormonal and cardiovascular parameters were examined in ten healthy adult men during sexual arousal and masturbation-induced orgasm. Blood was drawn continuously and cardiovascular parameters were constantly monitored. This procedure was conducted for each participant twice, both before and after a 3-week period of sexual abstinence. Plasma was subsequently analysed for concentrations of adrenaline, noradrenaline, cortisol, prolactin, luteinizing hormone and testosterone concentrations. Orgasm increased blood pressure, heart rate, plasma catecholamines and prolactin. These effects were observed both before and after sexual abstinence. In contrast, although plasma testosterone was unaltered by orgasm, higher testosterone concentrations were observed following the period of abstinence. These data demonstrate that acute abstinence does not change the neuroendocrine response to orgasm but does produce elevated levels of testosterone in males."
3. American population testosterone level dropped about 50 ng/dl for men at around age 64-65 between 2 groups of men born in 1920-1924 and 1930-1934, according to in http://jcem.endojournals.org/cgi/reprint/92/1/196. When the 1920-1924 group reached the median age 65, their mean testosterone level was 500 ng/dl; when the 1930-1934 group reached the median age 56 and 64, their mean testosterone was 529 ng/dl and 444 ng/dl, respectively. The 1930-1934 group has a testosterone drop rate at about 10.65 ng/dl per year during ages 56-64. This report also shows that the testosterone drop rate generally becomes faster for the men from 55 to 65. If we use the same annual drop rate of the 1930-1934 group, the extrapolated, averaged testosterone level of of 20 year old men born during 1930-1934 should be about 911 ng/dl.  Assuming that the mean 20-year old testosterone level for both groups are the same  is about  911 ng/dl, the overall-averaged testosterone drop for the 1920-1924 group is about 9.13 ng/dl/year, while the overall-averaged testosterone drop for the 1930-1934 group  is about 10.61 ng/dl/year  I suspect the higher masturbation/ejaculation frequency in the younger generation after the 60's sexual revolution resulted in a higher cortisol/ prolactin level (or faster ageing of the hypothalamus-pituitary-adrenal and -testicular axis) accelerates the testosterone drop, since some high-frequency over-masturbation young men experience male menopause (andropause) between ages 20-30. 
4. Our observations for healthy ejaculation frequency (or refraction times) vs age, in order to maximize the testosterone level, are:
  1. 4-7 times per week for teenagers of age 16-19.
  2. 3-6 times per week for young men of age 20-25.
  3. 3-5 times per week for young men of age 25-30.
  4. 2-4 times per week for men of age 30-45,
  5. 1-3 times per week for men of age 45-60,
  6. 1-2 times every 10 days for men of age 60-70.
  7. No more than once a week days after age 70
 Lovemaking orgasms stimulate the pituitary to release oxytocin for a faster recovery; while masturbation may not help the pituitary to release enough oxytocin. Therefore, the masturbation ejaculation frequency should be limited to the low limit as possible as you can. If your ejaculation orgasm produces sexual exhaustion symptoms,  your ejaculation frequency should be lower than the listed above.  The actual ejaculation frequency is associated the refraction (recovery time) of the hypothalamus-pituitary-adrenal, -thyroid and -testicular axis. The energetic time (full recovery with powering up) for a man having a morning (8 AM)  testosterone level at 350-400 nd/gl is about 7 days when his testosterone level reach its peak, over 500 ng/dl. If he keeps this ejaculation frequency, he will likely maintain his testosterone level around 450-550 ng/dl, thereafter. A man with a high testosterone level of 700 ng/dl or higher can re-erect  the penis in a few minutes after ejaculating if his pituitary doesn't overshoot his prolactin level, but it doesn't mean he can ejaculate again.  This is because the ability of penile re-erection can be associated with the dopamine nervous action on the pituitary oxytocin and prolactin release and the stimulation of testosterone, nitric oxide, prostaglandin E1 and  prostaglandin E2 stimulation on the prostate and penile erectile nerves.  Prostaglandin E2 can re-erect the post-ejaculating penis again when the oxytocin level is high and the prolactin level is not overshooting out of the range. The prostaglandin E2 induced erection usually accompanies a little pains in the prostate, urethra and penis. Even if you can re-erect your penis for sex again,  the post-ejaculation elevating cortisol and prolactin will start to lock up the adrenal and testicular function to drop your DHEA and testosterone production few hours after the first ejaculation. 
Like  psychological stress or exercise-induced stress, sex-induced stress induces excessive cortisol, prolactin and norepinephrine/epinpehrine release to lock up the hypothalamus-pituitary-adrenal and -testicular axis during sex or few hours later after orgasm or ejaculation. The neuro-immune-endocrine  responses to sex-induced stress can be delayed until cortisol starts to exert its effects on  the adrenal cortex, prolactin on the pituitary-testicular axis, and norepinephrine/epinephrine and its induced prolstaglandin E2 overheat the hypothalamus, pituitary, adrenal glands, testicles (ovaries), prostate, liver, lungs, heart and pancreases (for a high glucogan release) via the alpha- and beta -andrenergic receptors. For the same reason, people with chronic stress, no matter from which sources, generally have a lower testosterone level.  Over-trained athletes and soldiers and psychologically stressed-out persons are not exceptional. Testosterone and norepinephrine can positively or negatively interact each other through their receptors.  Initially,  testosterone induces norepinephrine release to give your arousal and heat, and then excessive norepinephrine with a high level of proactin and cortisol reduces testosterone release; on the other hand, without the inhibition effects of excessive prolactin and cortisol, norepinpehrine stimulates testosterone release via  action on both alpha- and beta-andrenergic receptors in the adrenal and testicles (ovaries) when the testosterone level is too low. To avoid the inhibition effects of excessive prolactin and cortisol, you need a normal dopamine-hypothlamaus-pituitary-adrenal function.  Any way, there are a lot of researches backing up the claim about the interaction among the nervous, immune and endocrine system:
Ref: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T99-42MFD98-12&_user=10&_rdoc=1&_fmt=&_orig=search
&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=2ddd3a7402479afca7ce03f4b59238f9  
http://hyper.ahajournals.org/cgi/content/abstract/32/5/880  
http://cat.inist.fr/?aModele=afficheN&cpsidt=2480820 
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000600009&lng=e&nrm=iso&tlng=e   
http://www.biolreprod.org/cgi/content/abstract/40/3/541 
http://www.popline.org/docs/0198/751348.html 
http://hyper.ahajournals.org/cgi/reprint/17/6/1104.pdf 
http://cat.inist.fr/?aModele=afficheN&cpsidt=15071810 
http://www.ncbi.nlm.nih.gov/pubmed/1337237 
http://endo.endojournals.org/cgi/content/full/144/11/4923  

The following research suggests the inflammatory cytokine IL-1beta and its induced prostaglandin E2 can stimulate the hypothalamus to induce release of norepinephrine, dopamine, and serotonin as a feedback control.
http://www.jneurosci.org/cgi/reprint/13/8/3574 

This article suggest norepinephrine control the feedback of  LH secretion in the hypothalamus-pituitary-testicular axis - http://www.popline.org/docs/0188/761130.html 

You will get more explanation in the following about the role of norepinephrine and epinephrine in the sexual arousal, orgasm responses, sexual exhaustion symptoms,  and neuro-immune function.

Neuroplasticit also occurs when changes in electrical excitability and changes in gene expression can long outlast the initial causal stimulus. For example,   airway inflammation in baby monkeys repeated ozone exposures results to persistent increase in the excitability of nucleus tractus solitarius neurons in the brain stem as described in Plasticity in Respiratory Motor Control Selected Contribution: Vagal neuroplasticity in nucleus tractus solitarius neurons after episodic ozone exposure in infant primates (http://jap.physiology.org/cgi/content/abstract/94/2/819?ijkey=0b358ac59f303cf9c8922f1afdf2b9d4a5889946&keytype2=tf_ipsecsha).
This is an adaptation of the respiratory motor responses, a part of biological evolution.  Vago-vagal reflex circuits controlling and modulating digestive functions from the oral cavity to the transverse colon can be activity-dependently plastic in controlling stomach behavioral and physiological homeostasis.( http://ajpgi.physiology.org/cgi/content/full/284/2/G180 ).  Nerves can regrow in a failure transplant heart. you can remodel the sympathetic nervous system with Neuroplasticity for better or worse ( http://hyper.ahajournals.org/cgi/content/full/47/2/143).  Biofeedback can train your cardiovascular function for better output. http://www.psychosomaticmedicine.org/cgi/reprint/65/5/796.pdf .  Meditation may induce short-term and long-term neural changes as described in http://www.pnas.org/cgi/content/full/101/46/16369 and http://www.pnas.org/content/101/46/16369.full#abstract-1 .  Meditation generally produces vagal or parasympathetic nervous plasticity, but can be highly dopaminergic and noradrenergic , depending on what types of parctices..  Some people who do it in a wrong way get sympathetic neuroplasticity for headaches or other  sympathetic nervous Fight and Flight responses. This also indicates the sensory and motor nerves in the central and peripheral nervous system can be plastic. ( http://www.jneurosci.org/cgi/content/full/25/44/10167  and http://www.research.va.gov/programs/JRRD/45_2/Forrester.pdf ) This also tell you that  you can reduce sexual urgency and may help you unhook yourself from sex addiction with Dr. Lin's ChiKong and anal breathing practices. You can improve your focusing and cognitive function with a focusing effect of acetylcholine (ACh)  on neuroplasticity of cortical networks. ACh not only increased selectively the efficacy of synapse-specific excitability-enhancing neuroplasticity,  but also prolonged the excitability diminution in case of asynchronous synapse-specific inputs and suppressed global excitability enhancements. ( http://www.jneurosci.org/cgi/content/full/27/52/14442  ).  That is why our pro-acetylcholine products ,such as Moodmax and ViaGrowth-IV , can improve your congestive function.

Sexual or orgasm addiction is due to the nervous plasticity of the hypothalamic paraventricular nucleus (PVN) where the dopamine, acetylcholine, oxytocinergic, noradrenergic (norepinephrine), adrenergic(epinephrine), autonomic (sympathetic and parasympathetic) vagal, glutamate, NOergic, GABAergic and serotonin  nervous system innervate. The nervous plastic remodeling occurs under a frequent oxytocin and norepinephrine stimulation during sex when the GABAergic and serotonin nervous function are too weak to modulate the dopamine-norepinephrine conversion and the noradrenergic nervous firing. The main source of  noradrenergic innervations of higher brain sites, including the hypothalamus and PVN, is the locus ceruleus (LC) where norepinephrine activates pro-inflammatory pyrogenic cytokins and protein kinases in LC  for prostaglandin E2 which,  in conjunction with action of oxytocin, let you feel high, arousing and exciting. Sex can increase the density of PVN dopamine beta-hydroxylase immunoreactivity (DBHir), so that the enzyme dopamine beta-hydroxylase can constantly convert dopamine to norepinephrine to keep on sexual fire, leading to addiction. Prostaglandin E2 is involved in the regulation of synaptic activity, transmission and plasticity, and in brain evolution. Prostaglandin E2 accelerates neuroplasticity.  You need prostaglandin E2 for neuroplasticity - learning, memory and addiction. Thus, you have to study hard (for more norepinephrine and prostaglandin E2)  to memorize contents of the books you read  in a short time. However, you use them (norepinephrine and prostaglandin E2)  for sex addiction, you will love sex more than your life.  Prostaglandin E2 can also degrade the short time memory and spatial navigation by enhancing membrane excitability and then inducing long-term synaptic plasticity in hippocampal perforant path-dentate gyrus synapses.
Ref: http://www.jneurosci.org/cgi/content/full/25/43/9858 
http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=2292143&blobtype=pdf 
http://www.nature.com/nm/journal/v7/n4/full/nm0401_414.html
http://ajpgi.physiology.org/cgi/content/full/277/1/G79  
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1430829 
http://jn.physiology.org/cgi/content/full/88/1/49 
http://ajpheart.physiology.org/cgi/content/full/291/6/H2847 
http://ajpheart.physiology.org/cgi/content/full/274/4/H1284 
http://ep.physoc.org/cgi/content/full/90/2/169 
http://www.jneurosci.org/cgi/content/full/24/35/7604/ 
http://physiologyonline.physiology.org/cgi/content/full/14/3/100 
http://ajpregu.physiology.org/cgi/content/full/292/4/R1717 
http://endo.endojournals.org/cgi/content/full/145/11/4917 
http://joe.endocrinology-journals.org/cgi/content/full/190/3/593 
http://www.acnp.org/g4/GN401000155/Default.htm and http://jn.physiology.org/cgi/content/abstract/87/6/2851?ijkey=5cee184dd3946b4945f9cc00585dec35e2d51349&keytype2=tf_ipsecsha 

Excessive sex also cause memory loss and learning inhibition, as reported in http://www.actionlove.com/extra/alzheimer.htm What happens inside your brain memory center - the hippocampus when you have excessive sex?  Does it make you become stupid?  Yes, it can produce destructive neuroplasticity.  Here, neuroplasticity is referred to the brain rewiring in response to changes in environment, experience or  brain chemistry. The brain areas related to memory formation and learning, such as the hippocampus and dentate gyrus, were highly plastic.  Neurons continue to be produced, synoptically deformed, and destroyed into adulthood. You can alternate your brain function in positive or negative way. The Ying-Type stress hormone cortisol is responsible for alternating structure and function of the hippocampus. Excessive cortisol inhibits adult neurogenesis in the dentate gyrus, and impairs hippocampus-dependent learning and memory, as described in.
http://www.kzoo.edu/psych/Karten%20et%20al.2005.pdf
Note: Cortisol is one of corticosteroid hormones and biologically active while cortisone is the biologically inert one. Cortisol is metabolized by the 11-beta hydroxysteroid dehydrogenase system (11-beta HSD), which consists of two enzymes: 11-beta HSD1 and 11-beta HSD2.
11-beta HSD1 utilizes the cofactor NADPH to convert biologically inert cortisone to biologically active cortisol. 
11-beta HSD2 utilizes the cofactor NAD+ to convert cortisol to cortisone.

Case example:
Chronic over-masturbation at 3 times a day since age 6 and 1-year marijuana smoking results in memory loss, terrible eye floaters, dizziness, severe depression, frequent urination, anxiety, insomnia, neck tremors, severe leg tremors, and restless leg syndrome (Parkison's disease or symptoms) for no more sexual orgasm
http://www.actionlove.com/cases/case15916.htm
Serotonin and GABA nervous deficiency and noradrenergic/sympathetic nervous excess can be caused by pregnant mother's caffeine or drug abuse or/and by individual chronic over-masturbation and drug abuse (marijuana, methamphetamine, cocaine, heroin or other nervous toxins), leading to severe eye floaters, dizziness, memory loss, depression, anxiety, tachycardia, penile numbness,  and psychological disorders (including suicidal tendency) for no more sexual orgasm
http://www.actionlove.com/cases/case15914.htm
Chronic Over-masturbation results in premature ejaculation, erectile dysfunction (going limp),  precum leakage, urethral itching/sensation, penile/groin/leg/prostate inflammatory pains, hair loss, irritation, anxiety, mood swing, loss concentration and absent mindedness for no more sexual orgasm
http://www.actionlove.com/cases/case15904.htm
Over-Masturbation at 20-25 times a day since age 7, masturbation addiction, masturbation withdrawal symptoms, and brain damage turned a gifted kid into a stupid junkie
http://www.actionlove.com/cases/case15605.htm
Pornography triggers dopamine-norepinephrine conversion for psychological stress; then, norepinephrine induces prostaglandin E2 production in your hypothalamic preoptic area, adrenal glands, testicles, prostate, seminal vesicles,  bulbourethral glands and urethra for psychologically stress-induce fever (brain overheating), body aches and pains, precum/semen leakage and premature ejaculation/orgasm. Addiction on the norepinephrine and prostaglandin E2 stimulation from pornography will produce withdrawal symptoms.
==> http://www.actionlove.com/cases/case15815.htm
The destructive testing results of over-masturbation from a 17-yearo-old boy - sexual exhaustion symptoms for no more life and sexual orgasm, including, body pains, arthritis, testicular pain, penile pain, prostate pain, back pain, face pain, gum pain, tinnitus (excessive glutamate and inflammatory hormone prostaglandin E2), headcahes, fatigue, anxiety, nightmare, chilliness and shivering attacks, hot flashing/fever (premature male menopause), cracking joints, fibromyalgia, impotence, Restless Leg Syndromes (pre-parkinson's disease) and so on.
==> http://www.actionlove.com/cases/case15655.htm

FDA Warnings: 
News Upadated (July 8, 2005): All the erectile PDE5 inhibiting drugs can cause sudden decreases or loss of eyesight (even blindness, under a very fancy name "Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)", as warned by the US FDA in in -
http://www.fda.gov/cder/drug/InfoSheets/patient/sildenafilPIS.htm 
http://www.fda.gov/cder/drug/infopage/cialis/default.htm or http://www.fda.gov/cder/consumerinfo/viagra/default.htm
http://www.fda.gov/cder/drug/InfoSheets/HCP/sildenafilHCP.htm  or http://www.pbm.va.gov/alerts/PDE5.pdf 
News Upadated (Oct. 18, 2007): All the erectile PDE5 inhibiting drugs can cause sudden decreases or loss of hearing, tinnitus and dizziness as warned by the US FDA in http://www.fda.gov/medwatch/safety/2007/safety07.htm#PDE5.  
In fact, Dr. Lin has documented the sex-induced nervous disorders since 1997 in our websites,  although these problems were well-addressed in the Chinese Sexual Bible "Suu-Nu Ching" and Medical Textbook "Yellow Emperor's Classic of Internal Medicine" around 2600 B.C..  Realizing the sexual exhaustion systems, Dr. Lin has developed the ViaPal-hGH formulas and other products to help you rejuvenate your exhausted brain/nervous and endocrine functions for health and then sex. Dr. Lin has also addressed the optimal, safe sexual/orgasm frequency for the different age groups of people without damaging the brain and neuro-endocrine system.
Health Canada Warning - http://www.hc-sc.gc.ca/ahc-asc/media/advisories-avis/2005/2005_83_e.html.
So, you should read this link about sex and vision too before taking erectile drugs - http://www.actionlove.com/extra/eyefloater.htm,  but don't have to die for SEX! 
The Root of Over-Masturbation/Excessive Sex:  
Male/Female Persistent Sexual Arousal Syndrome - http://www.actionlove.com/extra/psas.htm
Penile Enlargement Updated: The role of DHT, prostaglandins E-1/E-2/E-3, and Nitric Oxide in the penile enlargement for more sexual orgasm (Here is the fact: A balance action of prostaglandin E-1 and E-2 on the nerves and blood vessels allow the tissue to expand and stretch without pains. For example: pregnant women stretch and grow the uterus and abdomen without pains under a simultaneous, balanced action of prostaglandin E-1 and E-2,  but start labor contraction pains when prostaglandin E-2 overpower prostaglandin E-1, in conjunction with the action of oxytocin, cotisol and epinephrine!)
http://www.actionlove.com/cases/case13917.htm  
Natural Vaginal Rejuvenation and Tightness Updated: ballooning of the vaginal spongy tissues, G-spot erectile tissues, corpus cavernosum clitoridis, and vestibular bulbs will tighten up you vaginal orifice and canal. For detail please go to http://www.actionlove.com/extra/vsize.htm 
The basic principle of the penile and clitoral/G-spot ballooning is to turn the local skin into an endocrine organs for more DHEA,  DHT, testosterone, and prostaglandins production to feed the erectile tissues and nerves, as described in
http://www.fasebj.org/cgi/reprint/04-1968fjev1
and
http://edrv.endojournals.org/cgi/reprint/21/5/457

Excessive Sex for dark eye cycles, nips, labia minors, pelvic area, perineum clitoral/penile forskin:   Skin is a neuroendocrine organ. Chronic stimulation of sex organs can lead to over-production of α-MSH and Trapping excessive α-MSH in certain areas of skin results in extra skin darkness, particularly in eye cycles, nips, labia minors, penile and clitoral foreskin, and perineum if the local skin neuroendocrine function was working, but the local blood circulation becomes poor due to excessive noepinephrine or epinpehrine binding in the sympathetic andrenergic-α2 receptors of the blood vessels or a lack of nitric oxide and prostaglandins E1/E3 in the local tissues . α-MSH stimulates excessive production of melanin, a brown pigment manufactured by certain cells in the skin called melanocytes. Excessive melanin is responsible for dark skin color. This is called Hyperpigmentation. The dark skin as a result of chronically excessive sex-stress norepinephrine induced inflammatory hormone prostaglandin E2 stimulation is considered as Post-inflammatory hyperpigmentation. In this regard, the excess melanin is produced in the upper layer of skin (epidermis). The cells that normally produce brown pigment evenly across your skin go into overdrive and produce too much melanin. Then,  the pigmentation color is a darker shade of brown.
http://www.fasebj.org/cgi/content/full/21/4/976 
http://physrev.physiology.org/cgi/content/full/80/3/979
http://edrv.endojournals.org/cgi/content/full/21/5/457 

As of today,  a high level of prolactin has been realized as a promoter or co-initiator of breast and prostate cancers, in addition to disable the sexual function. It appears to play a key role in the development and progression of breast and prostate cancer and tumors.  So, keep your prolactin level in the normal range and avoid the synergistically biological effects of the prolactin on the estrogen or/and DHT receptors.

You will get another benefit from sex and orgasm if you get a resulted elevation of both GABA and glutathione which are converted from excitototoxicity glutamate. GABA is synthesized from glutamate using the enzyme L-glutamic acid decarboxylase and pyridoxal phosphate as a cofactor, and glutathione from the amino acids L-cysteine, L-glutamate and glycine in two adenosine triphosphate-dependent steps:   by combining L-glutamate and cysteine via the enzyme gamma-glutamylcysteine synthetase to form gamma-glutamylcysteine, and then adding glycine to gamma-glutamylcysteine via the enzyme glutathione synthetase to produce glutathione. Elevation of GABA with serotonin, norepinephrine and prolactin after sex or orgasm will trigger the pineal gland and retina to release melatonin for better sleeping, hGH production, nervous regrowth, neuro-endocrine restoration, cellular repair,  and shaper vision;  Elevating of glutathione can reduce the formation of  oxidative toxins, such as Hydrogen peroxide (H₂O₂),  associated with oxidative injury and cellular/nervous damage.  However, if you lack of these liver enzymes ( L-glutamic acid decarboxylase, pyridoxal phosphate , gamma-glutamylcysteine synthetase and glutathione synthetase)  and amino acids L-cysteine and glycine, you will get excitotoxicity and brain/nervous damage from your orgasm sponsoring neurotransmitters glutamate, dopamine, norepinephrine, epinephrine and histamine which stimulate the gene over-expression of monoamine oxidase in your brain, liver, kidneys, adrenal glands, heart and other organs for premature ageing, brain and nervous damage,  and sexual exhaustion symptoms (as listed in http://www.actionlove.com/cases/case9848.htm).

Sexual arousal, ejaculation or orgasm induces a burst of norepinephrine and epinephrine release.  For a health person, the norepinephrine and epinephrine release is supposed to stop in few minutes after sex and drops in maintaining the homeostasis. Overall, the norepinephrine and epinephrine level will stay higher for few hours.  Norepinephrine and epinephrine can trigger both proinflammatory and anti-inflammatory cytokines and kinases in the immune system via the stimulation of the alpha- and beta-adrenergic receptors.   Moderate increase in norepinephrne and epinephrine during and fater sex results in increase in the concentration of lymphocytes in the bloodstream for immune enhancemen; t and the anti-inflammatory cytokins overpowers the side effects produced by proinflammatory cyrockins.  That is why optimal sex, like moderate exercises, can improve your health and neuroimmune function. However, excessive norepinephrine induces more proinflammatory effects than anti-inflammatory ones, leading to excessive prostaglandin E2 production to set your brain and body on fire - over-heating, immune disorder and inflammatory responses. This is what you have to concern about.

My case collection since 1997 is given in
http://www.actionlove.com/extra/acne.htm and
http://www.actionlove.com/extra/hailoss.htm 
My intention is to have a statistical data (cases) to support the traditional Taoism's and Chinese Medical claims about the side effects of over-sex on the acne outbreak and hair loss. In the past, there have been a lot of disputes on this issue (for example, please read http://answers.yahoo.com/search/search_result;_ylt=AlClvcr4x7agkfBvF65HS6Hpy6IX;_ylv=3?p=over+masturbation ).  Luckily, I also have found the scientific research support on these claims. Scientifically, it is called the skin's and hair-follicle's hypothalamus-pituitary-adrenal axis or the skin/hair stress response axis - the response of the body to acute and chronic stress induced by temporarily or chronic over-sex activities. Under acute or chronic stress, neurohormones, neurotransmitters, neuropeptides and neurotrophins will stimulate a series of adaptation responses, leading to behavioral, cardiovascular, metabolic, endocrine and immunological changes. The most critical one is the immunological changes ranging from immune suppression to imflammation. Acne, skin allergy,  and hair loss can be considered as a result of inflammatory diseases. In fact,  psychological stress causes more inflammatory and autoimmune diseases than what you think. I have termed the resuted diseases as the Sexual Exhaustion Symptoms  if they are directly or indirectly induced by sex-induced stress - chronic or acute! If you still don't understand why excessive stress induces acne and hair loss, you should read the following links-
http://edrv.endojournals.org/cgi/reprint/21/5/457 ,
http://www.fasebj.org/cgi/reprint/04-1968fjev1,
http://edrv.endojournals.org/cgi/reprint/21/5/457,
http://www.psychosomaticmedicine.org/cgi/reprint/63/3/412,
http://www.tufts.edu/sackler/pharmacology/faculty/theoharides/documents/TiI-brain-skin.pdf,
http://edrv.endojournals.org/cgi/reprint/22/4/502,
http://www.fasebj.org/cgi/reprint/19/10/1332,
http://ajp.amjpathol.org/cgi/reprint/165/1/259,
http://www.nature.com/jid/journal/v122/n1/pdf/5602146a.pdf,
http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1868107&blobtype=pdf
and http://www.nature.com/jid/journal/v117/n2/pdf/5601158a.pdf

Excessive sex, drug/alcohol abuse, work overloads,  Over-eating (high-protein overdosing and high-tyramine foods), excessive caffeine intake, and excessive exercises can induce excessive stress hormone production for hair loss (actually, stopping hair regrowth after losing hair)  and acne outbreak - the sympathetic nervous fires in your skin and hair follicles. Sleeping disorders indicate excessive stress with insufficient serotonin and GABA nervous modulation on the pineal and retinal function.  Your acne and hair loss can also be associated with sleeping disorders.