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Case Study -  Constant Vaginal discharge, tastes and odors due to excessive progesterone
Reader1: 6/29/2002> 
I have had a constant vaginal discharge for a couple of years. It is often thick and white, and sometimes has a yellow tint to it. I have it all the time up until I start my period, and then it starts again once my period is over. I am not sexually active at all. What is it, and what causes it?


Dr. Lin: 6/30/2002>This is caused by excessive progesterone in your body.
The increase of progesterone will stimulate the cervix to produce white, thick discharge and, the same time, varies the metabolic substrates available to the bacterial flora in the vagina. As a result, The bacteria differ proportions of voltatile aliphatic acids, and gives distinctive odors, tastes and colors to vaginal secretions.
In the normal steroid synthesis, there are 2  metabolism pathways for progesterone:
1. Progesterone + liver enzyme 17alpha-hydroxylase (CYP17) => 17-Hydroxyprogesterone => androstenedione (or 11-Deoxycortisol) => testosterone/estrogen (or Cortisol). 
2. Progesterone + liver enzyme 21alpha-hydroxylase (CYP21) => Deoxycorticosterone ==> Corticosterone => 18-hyroxycorticosterone => Aldosterone.

If your liver function is too weak to provide sufficient enzymes CYP17 and CYP21, your progesterone level become too high.
Also check your cholesterol level. The liver enzyme desmolase + LDL Cholesterol => Progenolone => progesterone.

The liver function can be enhanced by the vagus (parasympathetic) nerves and by triggering the liver detoxification with some amino acids and herbs. The liver should produce the essential enzymes to metabolize the excessive steroids. This is supposed to be the liver detoxification job. In this regard, MoodMax can help.
Note: Progesterone-based birth control pills/implant/shot can cause this problem too.
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