Peyronies Disease – Deformation or hardening of genital smooth muscle

Peyronies Disease – Deformation or hardening of genital smooth muscle with uneven distribution of collagen scar tissues over the smooth muscle

Peyronies Disease is generally referred to the male genital deformation, but women have the similar problem – deformation, thinning or hardening of the genitourinary smooth muscle, which results in incontinence,  dryness, looseness, prolapse, dyspareunia or vaginismus, although it is invisible.

OK, first let’s consider the male problem.

The penile smooth muscle, like arterial ones,  can repair or regrow itself  via the stem cell’s  transforming growth factor-beta(3) (TGF-beta3) which regrows the local cells like embryo does . However, due to the penile blood flow restriction, or androgen hormone deficiency, or excessive drug toxins, there are insufficient active stem cells around the damaged tissue to release TGF-beta3  for regenerating the smooth muscle.  As a result, The damaged  (also, “nutritionally starved” ) cell  releases collagen protein, and activates cellular transforming growth factor-beta(1) (TGF-beta1) for a faster reconstruction and  reconnection of the damaged tissue.  This will further restrict the genitourinary blood circulation for more deformation, shrinkage, scarring and thinning of the smooth muscle. Ref: http://www.ncbi.nlm.nih.gov/pubmed/15291880

Chemical or mechanical damage, or degeneration of penile smooth muscles due to deficiency of androgen hormones (testosterone and/or DHT) or/and erectile factors ( nitric oxide (NO) and prostaglandins), is likely to disable the stem cells which result in activation of TGF-beta1 instead  of TGF-beta3. The embryo TGF-beta3 can multiply or duplicate the smooth muscle cells without a presence of collagen scar tissues.  Embryo TGF-beta3 helps a baby heal any wounds or cuts without any scars. As we get old, we will have less and less TGF-beta3, in particular,  in the genital smooth muscle cells which requires a lot of human growth hormones, androgen hormones, nitric oxide and prostaglandins to maintain the integrity of the smooth muscle.  If you can increase the cellular TGF-beta3 activities in the smooth muscle, you can or repair or regrow it, like a baby and puberty teenager does.

Chemical damage of penile tissues can be caused by medication or street drugs, diabetes, high stress hormones or prolactin,  and deficiency of oxytocin, hGH, DHEA, testosterone and DHT in the bloodstream.  The most destruction medication drugs for the penile smooth muscle include the beta blocker, 5-alpha reductase inhibitors (for hair regrowth or prostate enlargement), and LDL cholesterol lowering drugs.  Beta blockers constrict the penile arteries for poor blood circulation; 5-alpha reductase inhibitors cause DHT deficiency; the LDL lowering drugs result in deficiency of DHEA, testosterone and DHT.  On the other hands, all the street drugs are likely to cause severe damage of the smooth muscle by either disabling the hypothalamus-pituitary-testicular axis, killing the erectile nerves, enhancing the inflammatory hormone prostaglandin E2 synthesis while reducing the synthesis of other prostaglandins,  or even poisoning the adult stem cells.

Mechanical damage of the penile smooth muscle is very common for men who practice penile stretching or pumping.  When the smooth muscle matrix is forcefully stretched or expanded beyond its elastic capacity, collagen protein is released in an attempt to repair the damaged smooth tissue. In stead of repair, collagen protein hardens the damaged spot.   In addition to the over-strained damage, the smooth muscle can become fatigue when the tissue is subject to high-frequency vibration, even if the amplitude is small. Collagen protein starts to release all over the smooth muscle when the smooth muscle become fatigue.  This will result in reduction of the erectile ability of the smooth muscle, ending up with with hardening and shrinkage. Vibrator abusers, men or women, are likely to experience erectile dysfunction of the smooth muscle in the penis, urethra, clitoris or vagina. It also destroys or hardens the vagus nerve, leading to urinary or bowling incontinence.

The smooth muscle can become hardened in certain zones or spots.   For men, the collagen scar formation produces a crooked/bent or hour-glass shaped penis. For women, it results in external genital shrinkage and hardening, thinning (or scarring) of urethral and vaginal smoothing muscle, and vaginal enlargement. This is the female Peyronies Disease!  Since the female genital smooth muscle is hidden above the pelvic flood muscle, women won’t be aware of the Peyronies Disease even if they experience incontinence,  dryness, looseness, prolapse, dyspareunia or vaginismus!

Once we understand the causes of the problem, we can re-model them by activating the adult stem cells in the smooth muscle for TGF-beta3, accordingly:

1. take need ViaPal-hGH-P(3-010) and ArgiNOx (1-018), plus Omega-3  Fish Oil(2-005) and Vitamin D (2-004),  to help you gradually rejuvenate your neuro-endocrine function (increaseing testosterone and DHT level) and  boost your prostaglandin E-1/E-3 and Nitric Oxide production for healing. http://linstitute.apollohosting.com/store/index.html

(why should you maintain an above-averaged androgen hormone level?  please read
“Effects of Androgen on the Expression of Vascular Endothelial Growth Factor in the Penile Corpus Cavernosum”
by Eu Chang Hwanga, Kyung Jin Oha, Seung Il Junga, Noel N. Kimb, Kyu Youn Ahnc, and Kwangsung Park,
Urology, Volume 77, Issue 6, June 2011, Pages 1381–1386
http://www.sciencedirect.com/science/article/pii/S0090429511001099 )

and
2. Practice genital ballooning and massage with VIP Cream (1-015) to increase the smooth muscle blood flow, to stimulate the NO and prostaglandins release, and to  soften the hardened tissues. http://www.actionlove.com/WordPress/2014/02/25/theory-of-penile-ballooning-enlargement/  or
http://www.actionlove.com/extra/enlarge.htm

Noticeably, we have also developed the G-spot Ballooning method for women to rejuvenate and regrow the smooth muscle, as described in http://www.actionlove.com/WordPress/2015/08/14/g-spot-rejuvenation-and-natural-regrowth/

There are a lot of other benefits, as described in this article entitled: “How to perform Vagus Nerve Stimulation (VNS) from your bottom (pelvic floor) with VIP Cream , of course, without an electronic pulse generator?”  http://www.actionlove.com/WordPress/2016/01/09/how-to-perform-vagus-nerve-stimulation-vns-from-your-bottom-pelvic-floor-with-vip-cream-of-course-without-an-electronic-pulse-generator/

By the way, if you can not take ViaPal-hGH-P, you can switch to ViaPal-hGH-M (3-014), ViaPal-hGH-E (3-011), or ViaPal-hGH-S (3-013) instead.  You want to boost dopamine, but can not take ViaPla-hGH-P, you can switch to ViaPal-hGH-A (3-020) or ViaPal-hGH-F (3-022).  You can find a suitable formula from http://linstitute.apollohosting.com/store/index.html

Or send it e-mail over from http://www.taonetworks.net/mailform.html

References:

  1.  Dulak J1, Józkowicz A, Dembinska-Kiec A, Guevara I, Zdzienicka A, Zmudzinska-Grochot D, Florek I, Wójtowicz A, Szuba A, and Cooke JP., ” Nitric oxide induces the synthesis of vascular endothelial growth factor by rat vascular smooth muscle cells.” Arterioscler Thromb Vasc Biol. 2000 Mar;20(3):659-66. http://atvb.ahajournals.org/content/20/3/659.full.pdf+html
  2.  Eu Chang Hwanga, Kyung Jin Oha, Seung Il Junga, Noel N. Kimb, Kyu Youn Ahnc, and Kwangsung Park,  “Effects of Androgen on the Expression of Vascular Endothelial Growth Factor in the Penile Corpus Cavernosum”
    Urology, Volume 77, Issue 6, June 2011, Pages 1381–1386
    http://www.sciencedirect.com/science/article/pii/S0090429511001099
  3. Yamanaka M1, Shirai M, Shiina H, Tanaka Y, Enokida H, Tsujimura A, Matsumiya K, Okuyama A, and Dahiya R.,
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    http://www.ncbi.nlm.nih.gov/pubmed/15592104
  4.  Shirai M1, Yamanaka M, Shiina H, Igawa M, Kawakami T, Ishii N, Lue TF, Fujime M, and Dahiya R., “Vascular endothelial growth factor restores erectile function through modulation of the insulin-like growth factor system and sex hormone receptors in diabetic rat.” Biochem Biophys Res Commun. 2006 Mar 17;341(3):755-62. Epub 2006 Jan 19.
    http://www.ncbi.nlm.nih.gov/pubmed/16455052
  5. Lin CS1, Lue TF., “Growth factor therapy and neuronal nitric oxide synthase.” Int J Impot Res. 2004 Jun;16 Suppl 1:S38-9. http://www.ncbi.nlm.nih.gov/pubmed/15224135
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  7.  Kingston PA1, Sinha S, Appleby CE, David A, Verakis T, Castro MG, Lowenstein PR, and Heagerty AM, “Adenovirus-mediated gene transfer of transforming growth factor-beta3, but not transforming growth factor-beta1, inhibits constrictive remodeling and reduces luminal loss after coronary angioplasty.” Circulation. 2003 Dec 2;108(22):2819-25. Epub 2003 Nov 24. http://circ.ahajournals.org/content/108/22/2819.full.pdf+html
  8.  Deasy BM1, Feduska JM, Payne TR, Li Y, Ambrosio F, and Huard J, “Effect of VEGF on the regenerative capacity of muscle stem cells in dystrophic skeletal muscle.”  Mol Ther. 2009 Oct;17(10):1788-98. doi: 10.1038/mt.2009.136. Epub 2009 Jul 14. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835014/pdf/mt2009136a.pdf
  9.  Beckman SA1, Chen WC, Tang Y, Proto JD, Mlakar L, Wang B, Huard J., “Beneficial effect of mechanical stimulation on the regenerative potential of muscle-derived stem cells is lost by inhibiting vascular endothelial growth factor. “Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):2004-12. doi: 10.1161/ATVBAHA.11http://www.ncbi.nlm.nih.gov/pubmed/23723372#2.301166. Epub 2013 May 30.  http://atvb.ahajournals.org/content/33/8/2004.full.pdf+html
  10.  Andrzejewski W, Kassolik K, Kobierzycki C1, Grzegrzolka J, Ratajczak-Wielgomas K, Jablonska K, Halski T, Dziegiel P, Gworys B, and Podhorska-Okolow M., “Increased skeletal muscle expression of VEGF induced by massage and exercise.”  Folia Histochem Cytobiol. 2015;53(2):145-51. doi: 10.5603/FHC.a2015.0013. Epub 2015 Jul 7.   https://journals.viamedica.pl/folia_histochemica_cytobiologica/article/view/FHC.a2015.0013/29409
  11.  Best TM1, Gharaibeh B, and  Huard J. “Stem cells, angiogenesis and muscle healing: a potential role in massage therapies? ”  Br J Sports Med. 2013 Jun;47(9):556-60. doi: 10.1136/bjsports-2012-091685. Epub 2012 Nov 29.  http://www.ncbi.nlm.nih.gov/pubmed/23197410
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