Orgasm, Premature Ejaculation, and Histamine Receptors

Orgasm releases extra histamine by mast cells ( under the stimulation of norepinephrine due to a rapid conversion of  dopamine-to-norepinephrine in the hypothalamus and adrenal glands during sexual encounter and even after orgasm. In fact, orgasm is a response of the stress axis, the hypothalamus-pituitary-adrenal axis, to sexual stimulation. This axis releases norepinephrine, epinephrine, oxytcoin, prolactin and Arginine vasopressin (AVP); drops the central dopamine; and inhibits the central serotonin and acetylcholine synthesis by elevation of histamine and glutamate, resulting in alternation of the psychology, psychiatry and physiology.

File:Histamine3d.pngFile:Histamin - Histamine.svg

The solution for premature ejaculation is: mitigate the abrupt dopamine-norepinephrine conversion, and block the action norepinephrine and epinephrine on the central noradrenergic and adrenergic) and sympathetic nervous adrenergic alpha receptors.

The receptors affected by histamine are given below.  H2 seems producing positive effects, but H1 can give you positive and some negative (such as itching, asthma, pain, dizziness, an so on) effects,  and H3, which serves as a feedback control of norepinephrine release but also negatively inhibit acetylcholine and serotonin release in the Central Nervous System (CNS) for memory loss, depression and weak cholinergic/vagal and serotonin nervous control.  Thus, H1 and H3 receptors generate sexual exhaustion symptoms.  The H1 receptors in the clitoris, urethra, and  vaginal endothelial cells (particularly, around the G-spot) trigger orgasm responses via the vagal nerves and the  sympathetic autonomic reflex arcs of Discs L1-L4 for women; they produce hypersensitive sensation and induces ejaculation urgency,  premature ejaculation or precum/semen leakage, leading to activate the  sympathetic autonomic reflex arcs of Discs L1-L4 (where ejaculation generator cells are!) for men during sexual encounter. Histamine can short the sympathetic autonomic nervous reflex arcs of Discs L1-L4 for men and women. For men, the result is known as premature ejaculation; for women, it is called premature orgasm, which may be associated with persistent sexual arousal,  female ejaculation or/and stress incontinence (orgasm is a sex-stress response!).

Premature ejaculation is a very complicated tissue.
Main possible causes:
1. The prostate abrasion and poor seminal quality due to over-masturbation.
It requires a long-term prostaglandin E1/E3 and beta-endophrin therapy with Viapal-hGH-J (3-015) (or ViaPal-hGH-P(3-010)), and 5-HTP (2-001) ,  plus Fish oil  (2-005) and Vitamin D(2-004) daily.

2.  Drug abuse.
It requires a long-term nervous detoxification with Viapal-hGH-J (3-015) , DeToxiA (1-017) and 5-HTP (2-001), plus Fish oil  (2-005) and Vitamin D(2-004) daily.

3.  a low  Serotonin level in the brain.
MoodMax and 5-HTP can help
4.  over-training of the nervous L1-L3 reflex arcs  of the PC and prostate muscles.
a long term Anal breathing practice can solve the problem

5.  weak erection.
Power your erection with Viapal-hGH-J (3-015) (or ViaPal-hGH-P (3-010) if you are older than 30) and ArgiNOx (1-018)

6. Change semen chemistry by increasing the prostaglandins E1/E3, beta-endorphrin, serotonin, GABA and melatonin concentration and by reducing the norepinephrine, epinephrine, histamine and prostaglandin E2 concentration. This can be achieved by Viapal-hGH-J (3-015) (or ViaPal-hGH-P(3-010)),  ArgiNOx (1-018) and 5-HTP (2-001) (or PinealTonin (2-002)) ,  plus Fish oil  (2-005) ( + 81 mg Aspirin (during the night) and Vitamins D(2-004) A 10000 IU and E 200 IU daily.

We use 5-HP(or PinealTonin) , ArgiNOx, ViaGrowth-III (or ViaGrowth-IV)+ MoodMax + DopaFIbra, Fish Oil (Omega-3 EPA  (647 mg) (+ 81 mg Aspirin)  and Vitamins D 2000 IU and E 200 IU.
5-HTP + MoodMax + EPA  boost the cholinergic,  serotonin and GABA nervous control in the hypothalamic dopamine-norepeinephrine conversion, and power the parasympathetic nervous function to counterbalance  the sympathetic nervous function.
Our 5-HTP also contains a high dose of B3 (Niacin) to increase prostaglandin D2 production for relax the blood-brain tight junction for brain and nervous nutrients to penetrate into the brain and nervous system. Prostaglandin D2 also dilates arteries and capillaries for better blood circulation. B3 also increases the serotonin synthesis.
DopaFibra + ViaGrowth-III increase androgen hormones,  charge the central  dopaminergic nervous system and the parasympathetic nervous system,  and block the adrenergic alpha receptors, so that norpeinephrine and epinephrine can stimulate the adrenergic beta receptors for arterial dilation,  more blood flow and beta-endorphin release.   Beta-endorphin in the brain and semen can cool down the sympathetic nervous function.
Omega 3 with Aspirin 81 mg ( ), Vitamins D and E will also increase testosterone and semen production while blocking the inflammatory hormones and histamine release in the seminal vesicles and prostate.  They also change the semen chemistry by increasing prostaglandins E1 and E3 while reducing prostaglandin E2.
Reducing the sympathetic nervous function, increasing beta-endorphin/acetylcholine/serotonin/GABA/prostaglaninds E1/E2 and androgen hormone testosterone/DHT, and reducing norepinephrine/prostaglandin E2 will reduce histamine release.
Premature ejaculation, the sympathetic nervous fight response to sexual stimulation,  occurs when the prostate,  seminal vesicles, urethra, and  bulbourethral glands cook up more prostaglandin E2 and histamine, as inflammatory and sensitization hormones, in the synthesizing fluids (precum and semen)  under the sexual-induced excessive hypothalamic and adrenal dopamine- norepinephrine conversion.
We use the same formula to knock the bladder anxiety, over-reactive bladder, and stress induced incontinence.
There is another sympathetic nervous response to sex,  known as sympathetic nervous flight.  When the dopamine nervous function becomes too weak to stimulate the pituitary glands for sex, the pituitary gland releases insufficient oxytocin but excessive prolactin to constrict the arteries and retrieve the blood from the brain, penis (the vagina or clitoris for women)  and testicles, so that the penis (the clitoris and G-spot) go(es) limp.  The sympathetic nervous flight response to sex will force you to contract the PC muscles and the prostate to stimulate L1-L3 and S2-S4 for erection. Stimulation of L1-L3 sympathetic nerves activates the autonomic/sympathetic nervous reflex arcs (ejaculation/orgasm reflex arcs) in Discs L1 – L3 for precum release, semen emission and expulsion (ejaculation).
The solution for the sympathetic-nervous-flight-induced the sympathetic nervous fight is to block the autonomic nervous reflex arcs in Discs L1-L3 by my Anal Breathing training that alternates the autonomic nervous reflex arcs from L1-L3 to S1-S4.
Chronic masturbation for a fast ejaculation release usually trains the L1-L3 autonomic reflex arcs into a neuroplasticity state. If you got it, you have to de-train your nervous reflex arcs.
Here are the references for Anal Breathing;

I invented the Anal Breathing to block the nervous reflex arcs of L1-L3, as I published in my 1997 book.
Recently,  researchers discovered the L3-L4 reflex arcs contains “ejaculation generator” cells. I like the term.

Histamine receptors ( )
Receptor  Mechanism     Function Antagonists (Drugs)
H1  Gq
H2  Gs
↑ Ca2+
H3  Gi
H4 Gi
Type Location Function
H1 histamine receptor Found on smooth          muscleendothelium, and central nervous system tissue Causes bronchoconstriction, bronchial smooth muscle contraction, vasodilation, separation of endothelial cells (responsible for hives), and pain and itchingdue to insect stings; the primary receptors involved in allergic rhinitis symptoms and motion sickness; sleep and appetite suppression.
H2 histamine receptor Located on parietal cells and vascular smooth muscle cells Primarily involved in vasodilation. Also stimulate gastric acid secretion
H3 histamine receptor Found on central nervous system and to a lesser extentperipheral nervous system tissue Decreased neurotransmitter release: histamine, acetylcholinenorepinephrineserotonin
H4 histamine receptor Found primarily in the basophils and in the bone marrow. It is also found on thymussmall intestinespleen, and colon. Plays a role in chemotaxis.